properly, to be dense, i.e. tough or severe (in various applications)
KJV Renderings
be cruel, be fiercer, make grievous, be ((ask a), be in, have, seem, would) hard(-en, (labour), -ly, thing), be sore, (be, make) stiff(-en, (-necked)).
Word Analysis
Root: קשהVerbEN: when she was in hard laborES: al dificultársele